Dr. Diaz-Arrastia is Professor of Neurology, University of Pennsylvania Perelman School of Medicine, a role he assumed in July, 2016. At Penn he serves as Director of Clinical Traumatic Brain Injury (TBI) Research and Associate Director of the Penn Center for Brain Injury and Repair. Dr. Diaz-Arrastia’s research interests have been focused on understanding the molecular, cellular, and tissue level mechanisms of trauma-induced neuroregeneration and injury-related synaptic plasticity, with the goal of developing effective therapies.
Dr. Diaz-Arrastia received his MD and PhD degrees at Baylor College of Medicine in 1988, and after an internship Beth Israel Hospital and the Harvard Medical School, he trained in neurology at Columbia-Presbyterian Medical Center. He was on the faculty at the University of Texas Southwestern from 1993 to 2011, where he rose through the ranks from Assistant to Full Professor of Neurology. From 2011 to 2016 he was Professor of Neurology at the Uniformed Services University of the Health Sciences (USUHS), and Director of Clinical Research at the Center for Neuroscience and Regenerative Medicine, a federal intramural research program focused on TBI at USUHS and the National Institutes of Health.
Dr. Diaz-Arrastia has published over 170 primary research papers, as well as over 40 invited reviews and book chapters. He has also served in several national committees related to TBI and post-traumatic epilepsy, convened by the Institute of Medicine, the National Institute of Neurological Disorders and Stroke, the National Institute of Aging, the Department of Defense, and the Veterans Administration.
Dr. Hartings obtained his B.S. in Biological Sciences at the University of Notre Dame with magna cum laude and Distinguished Military Graduate distinction, and subsequently earned a doctorate in Neuroscience at the University of Pittsburgh. He then served in the U.S. Army at the Walter Reed Army Institute of Research for 8 years, separating from service at the rank of Major. In 2008, he joined the Department of Neurosurgery, University of Cincinnati College of Medicine, where is now an Associate Professor.
Dr. Hartings has distinguished himself in both laboratory and clinical research on acute brain injury, contributing extensively to the current understanding of spreading depolarizations as a mechanism of acute lesion development in cerebral gray matter. His preclinical studies utilize swine and rodent models of cerebral ischemia, hemorrhage, and brain trauma. In clinical research, he leads multi-center efforts to monitor spreading depolarizations by electrocorticography in severe brain trauma, and is co-founder of the translational consortium, Co-Operative Studies on Brain Injury Depolarizations (COSBID). Dr. Hartings has received several major grants from the Department of Defense and has been recognized as a Hero of Military Medicine and a finalist in the Cincinnati Business Courier’s Health Care Heroes. Dr. Hartings is a member of the National Neurotrauma Society, the Neurocritical Care Society, and the International Society for Cerebral Blood Flow and Metabolism, and is an avid brewer and marathon runner.
Martin Lauritzen is an MD from the University of Copenhagen (UCPH) from 1978 and got his DMedSci degree from in 1988 after spending a year with Charles Nicholson at New York University. Martin is a certified specialist in and professor of Clinical neurophysiology and Translational neurobiology at the National Hospital and UCPH. Martin has spent the main part of his professional life as a translational neurobiologist. His main interests are mechanisms of acute brain damage, brain blood flow, aging and the blood brain barrier.
Three selected papers:
Khennouf L, Gesslein B, Brazhe A, Octeau JC, Kutuzov N, Khakh BS, Lauritzen M. Active role of capillary pericytes during stimulation-induced activity and spreading depolarization. Brain 2018, July, 141 (7); 2032–2046. https://doi.org/10.1093/brain/awy143
Cai C, Fordsmann J, Jensen SH, Hald BO, Gesslein B, Lønstrup M, Brodin B, Lauritzen M. Conducted vascular responses in brain capillaries by synaptic activity and ATP in mouse cerebral cortex. Proc Natl Acad Sci USA 2018, https://doi.org/10.1073/pnas.1707702115
Kutuzov N, Flyvbjerg H, Lauritzen M. Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood-brain barrier. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):E9429-E9438. doi: 10.1073/pnas.1802155115. Epub 2018 Sep 14.
Dr. Leigh did his undergraduate training at Johns Hopkins University where he majored in Biomedical Engineering and Electrical & Computer Engineering. He then attended medical school at Case Western Reserve University and completed a medical internship and neurology residency at New York Presbyterian Hospital Weill Cornell Medical Center where he received the Distinguished Housestaff Award and was named Chief Resident in Neurology. He returned to Johns Hopkins for stroke fellowship and subsequently stayed on as neurology faculty with a secondary appointment in the department of radiology. In 2014, Dr. Leigh was recruited to the NINDS Intramural Stroke Branch as an Assistant Clinical Investigator. Dr. Leigh heads the Neuro Vascular Brain Imaging Unit, which uses MRI to study disease states that occur at the interface between blood vessels and the brain.
Dr Jose I Suarez Professor of Anesthesiology and Critical Care Medicine, Neurology, and Neurosurgery and Director of the Neurocritical Care Division at the Johns Hopkins University in Baltimore, MD. Dr Suarez has authored or co-authored over 160 publications in the areas of stroke and critical care neurology and neurosurgery in reputable journals including the New England Journal of Medicine, JAMA, Stroke, Critical Care Medicine, and Neurology. He is a member of the Editorial Board of Stroke. He is also a member of the Board of Directors and President of the Neurocritical Care Society. Dr Suarez areas of research interest include subarachnoid hemorrhage, acute ischemic stroke, cerebral edema, and outcomes in neurocritical care. He has been the principal investigators or co-investigator in important clinical trials investigating neuroprotection, blood pressure management, and stem cell infusions in patients with subarachnoid hemorrhage, intracranial hemorrhage, and subarachnoid hemorrhage, and cerebral physiology at high altitude and human space travel ground analogs. Dr Suarez was the PI for the NINDS-funded ALISAH Multicenter Pilot Study and is the PI for the ALISAH II International Multicenter Phase II clinical trial. Dr Suarez also has been a member of DSMB for several Phase III clinical trials including the NINDS-funded TBI in Latin America Lifespan Analysis and a member of the Executive Committee for the NINDS-funded ATACH II Trial. Dr Suarez has served at several research study sections including NSD-K (NINDS/NIH), BRAIN (AHA/ASA), Hong Kong Research Council. Dr Suarez was the founder of the Neurocritical Care Research Network (NCRN), which is composed of 260 neurocritical care units and investigators from 47 centers and have recently completed the PRINCE Study, the first observational study investigating the practice of neurocritical care.